ea0010p79 | Steroids to include Cushing's | SFE2005
Artsruni I
, Matinyan K
, Atanesyan L
, Melnikova-Sharova M
, Gevorgyan E
It is well known that glucocorticoid (GC)-induced apoptosis in thymocytes is triggered via glucocorticoid receptor activation. Nevertheless, the mechanism of paradoxical promoting effect of glucocorticoids on thymocytes survival and GC -suppression of age-associated thymic involution [1] is poorly understood. It is reasonable to propose that irreversible apoptotic DNA fragmentation can be an important regulatory step in apoptosis. A series of findings suggest that activation o...